C19 Notes

Comparison of nasal swab tests & saliva tests

Author Topic: Comparison of nasal swab tests & saliva tests  (Read 671 times)

stog

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Comparison of nasal swab tests & saliva tests
« on: May 02, 2020, 08:09:21 PM »
Conclusions: Supervised self-collected oral fluid and nasal swab specimens performed similarly to, if not better than clinician-collected nasopharyngeal swab specimens for the detection of SARS-CoV-2 infection.

No sample type captured all SARS-CoV-2 infections, suggesting potential heterogeneity in the distribution of viral load in different parts of the respiratory tract between individuals.

Supervised self-collection performed comparably to clinician collection and would allow for rapid expansion of testing capacity in the United States by reducing the need for trained healthcare workers, reducing exposure of healthcare workers, and reducing the amount of PPE (personal protective equipment) being used for testing during a critical shortage.


https://www.medrxiv.org/content/10.1101/2020.04.11.20062372v1
« Last Edit: May 15, 2020, 05:01:40 PM by stog »

stog

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Re: Comparison of nasal swab tests & saliva tests
« Reply #1 on: May 02, 2020, 08:15:01 PM »
Mark asked

Quote
Thanks again, but I still do not see any evidence of the application of these findings in practice. This uses a tiny sample and awaits peer review.

 indeed but the swab tests have been in action longer and are giving circa 70% accuracy

(mind you how would they know -- if there wasn't a live-in or a follow up, to ask about symptoms or indeed the asymptomatic negatives that were really positives

either way it's a guide and a help so long as it is employed, and 'our lot' are so centralised, they refused an initial chance to get the new kits which can be posted out (better than a letter from Boris methinks

re peer review, tiny samples etc -- true but these are extreme times and that is why emergency license has been given with conditions to data collect etc etc

also at least  they can now for example double test if required ie a confirmatory swab test after a saliva or vice a versa if it is for front line staff -- so we should know more info as roll-out continues.

This sort of EUA waiver though i think must not be actioned where vaccine trials are approaching production.

There needs to be care there for sure.

==

Look up results, trials for the present swab tests, whether they too were released on 'exceptions or emergency licensing. Find out their accuracy data (which as I say both Val and I have read is around 70%.

the saliva tests are now in the wild being used for the USAF and the States of California and Arizona in fair and increasing numbers, so data should be forthcoming and ongoing.

Mind you double blind testing etc isn't exactly ethical in these situations. but there will be follow up or double testing so time will tell.


==
« Last Edit: May 02, 2020, 09:30:07 PM by stog »

stog

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Re: Comparison of nasal swab tests & saliva tests
« Reply #2 on: May 14, 2020, 12:41:08 PM »
this article contains the most recent info on the oral tests with this interview from May 4th https://dot.la/coronavirus-rapid-test-curative-los-angeles-2645906983.html


>
Quote
Oral fluids is the technical term, which is slightly different from saliva. Our protocol involves having the person cough first, which releases virus from the upper and lower respiratory tract. Some of that is then caught in the saliva, and also viruses in the saliva. The idea is you're effectively sampling multiple sites at once, which we think gives a slight increase in the sensitivity of the testing.