another great benefit of looking for the normal response, can be seen in a study which "documents a robust antiviral immune response to SARS-CoV-2 in a group of 20 adults who had recovered from COVID-19. The findings show that the body’s immune system is able to recognize SARS-CoV-2 in many ways, dispelling fears that the virus may elude ongoing efforts to create an effective vaccine."
"And, although these results don’t preclude that the immune response to SARS-CoV-2 may be detrimental, they provide an important baseline against which individuals’ immune responses can be compared; or, as Sette likes to put it, “if you can get a picture of something, you can discuss whether you like it or not but if there’s no picture there’s nothing to discuss.”Information about immunity to SARS-CoV-2, both in the context of COVID-19 disease pathogenesis and in the context of how to develop a good vaccine, remains limited. But developing a vaccine and predicting how the coronavirus pandemic will unfold until such a vaccine is available are both contingent upon the understanding of whether the immune system can mount a substantial and lasting response to SARS-CoV-2 and whether exposure to other, common, circulating coronaviruses provides any kind of protective immunity
A collaboration between the labs of Alessandro Sette, Dr. Biol. Sci., professor in the Center for Infectious Disease and Vaccine Research, and Shane Crotty, PhD, professor at La Jolla Institute for Immunology, is starting to fill in the massive knowledge gap and is providing the first cellular immunology data.Their work, published in Cell in a paper titled, “Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals,” studied T cell and antibody immune responses in average COVID-19 cases.
“We specifically chose to study people who had a normal disease course and didn’t require hospitalization to provide a solid benchmark for what a normal immune response looks like, since the virus can do some very unusual things in some people,”
“We have a solid starting foundation to now ask whether there’s a difference in the type of immune response in people who have severe outcomes and require hospitalization versus people who can recover at home or are even asymptomatic,” added Sette. “But not only that, we now have an important tool to determine whether the immune response in people who have received an experimental vaccine resembles what you would expect to see in a protective immune response to COVID-19, as opposed to an insufficient or detrimental response.”
« Last Edit: June 07, 2020, 03:42:09 PM by stog »